Towards optimal sensor deployment for location tracking in smart home

International audienceAmbient Assisted Living (AAL) aims to ease the daily living and working environmentfor disabled/elderly peopleat home. AAL use information and communication technology based on sensors data. These sensors are generally placed randomly without taking into account the layout of buildings and rooms. In this paper, we develop a mathematical model foroptimal sensor placement in order (i) to optimize the sensor number with regard to room features, (ii) to ensure a reliability level in sensor networkconsidering a sensor failure rate. This placement ensures the targettracking in smart home sinceoptimizing sensorplacement allow us to distinguish different zonesand consequently, to identify the target location, according to the activated sensors

Towards optimal sensor deployment for location tracking in smart home

International audienceAmbient Assisted Living (AAL) aims to ease the daily living and working environmentfor disabled/elderly peopleat home. AAL use information and communication technology based on sensors data. These sensors are generally placed randomly without taking into account the layout of buildings and rooms. In this paper, we develop a mathematical model foroptimal sensor placement in order (i) to optimize the sensor number with regard to room features, (ii) to ensure a reliability level in sensor networkconsidering a sensor failure rate. This placement ensures the targettracking in smart home sinceoptimizing sensorplacement allow us to distinguish different zonesand consequently, to identify the target location, according to the activated sensors

Kinematic Design of a Lighting Robotic Arm for Operating Room

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INFLUENCE OF AUXETIC STRUCTURE PARAMATERS ON DYNAMIC IMPACT ENERGY ABSORPTION

International audienceThe present work focuses on the dynamic crushing response of 2D re-entrant auxetic honeycomb by extending previous published models in order to include more design parameters (specific geometrical ratios and/or material properties). If the crushing velocity is constant, the energy absorption occurs at a constant plateau stress up to densification of the structure. An analytical equation based on shock waves propagation analogy in a rigid, perfectly plastic, locking material model is deduced from the study of periodic collapse of the structure. Our analysis enables to theoretically predict the dynamic crushing strength. The formulation depends on the geometric and the material characteristics of the auxetic but also on the impact velocity. Two series of Finite Element simulations of quasi-static and dynamic compressive test of an auxetic structure were carried out using the RADIOSS TM explicit solver. The first simulation series consist of a crushing plate loading the structure at a constant imposed velocity (0.5 m/s up to 100 m/s). Results show good accordance between analytical and Finite Element results. The time history of the cellstrain (ratio of deformed cell height to initial cell height) in the crushing direction shows that the peaks observed in the stress-strain curve of the entire structure are linked to complete crushing of each unit cell within a row. The second simulation series replicates the impact of the plate on the structure (initial plate velocities 50 m/s up to 100 m/s). The numerical simulations presented in this study, make it possible to relate the cell-strain, energy absorption and geometrical/material parameters of the auxetic structure

Design Process of a New Lighting Robotic Arm for Operating Room

International audienceIn this paper, we present the design process followed to conceive a lighting robotic arm dedicated to operating rooms. During a surgical procedure, the use of a high quality lighting system is essential to the successful completion of the surgical task. Indeed, the intensity and incidence of the light projection must be controlled according to the surgeon needs. However, surgeons cannot directly manipulate the lighting dome by hand because of aseptic reasons. First of all, we present the medical specifications used to define the technological and robotic needs, provided from real experiments and observations in operating room. Then, a complete topological synthesis has been applied to choose the most adequate kinematic solution. A kinematic simulator, as well as a prototype, have been developed to validate the effectiveness of the selected solution. Finally, we propose the use of a dynamic analysis, based on a Newton-Euler algorithm, to correctly choose the joint actuators

SAR156497, an Exquisitely Selective Inhibitor of Aurora Kinases

The Aurora family of serine/threonine kinases is essential for mitosis. Their crucial role in cell cycle regulation and aberrant expression in a broad range of malignancies have been demonstrated and have prompted intensive search for small molecule Aurora inhibitors. Indeed, over 10 of them have reached the clinic as potential anticancer therapies. We report herein the discovery and optimization of a novel series of tricyclic molecules that has led to SAR156497, an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy. We also provide insights into its mode of binding to its target proteins, which could explain its selectivity